Road to Vegas: 5 matchups to watch in Week 6 of college football

The most anticipated game of Week 6 is the SEC showdown between Georgia and Alabama in Tuscaloosa, where Hurricane Isaias may impact play along the Gulf Coast. Georgia leads the nation in scoring at 51.4 points per game, while Alabama averages 49.6 points. Georgia is 2-7 against Alabama under coach Kirby Smart but won the 2025 SEC championship game 28-7 in their last meeting. Georgia quarterback Gunner Stockton threw for 295 yards and three touchdowns in a 38-14 win over Vanderbilt, and Alabama’s Keelon Russell accounted for four scores in a 56-23 victory over Mississippi State.

In the Big Ten, undefeated Indiana (5-0) faces Nebraska (5-0), with Indiana coming off a 47-15 win over Rutgers, highlighted by Turbo Richard’s 204 rushing yards and a touchdown and Josh Hoover’s four touchdown passes. Nebraska’s Anthony Colandrea has thrown 13 touchdown passes with two interceptions, but the Cornhuskers have not beaten a ranked team since 2016 and are 0-9 against Top 25 opponents under coach Matt Rhule. UCLA, 4-0 under first-year coach Bob Chesney, hosts Oregon, with Bruins running back Wayne Knight averaging 9.1 yards per carry and nine touchdowns. Oregon will start Dylan Raiola at quarterback after Dante Moore was ruled out due to a concussion; Raiola went 19 of 25 for 289 yards and two touchdowns in relief against USC.

In the Red River Rivalry, Texas (3-1) hosts Oklahoma (2-2), with the Longhorns coming off a 20-17 win at Tennessee and a bye. Texas quarterback Arch Manning and the offense have been inconsistent, but the defense has recorded 15 sacks in four games. Oklahoma quarterback John Mateer has six turnovers in four games, including three in a 41-13 loss to Georgia, and the Sooners rank 133rd nationally in rushing yards per carry at 2.9. Oklahoma may get a boost from running back Tory Blaylock, who should be near full health after a bye. LSU (4-1) defeated McNeese State 63-14, with quarterback Sam Leavitt completing 66.2 percent of his passes for 1,220 yards, eight touchdowns, and six rushing touchdowns when avoiding turnovers.

Sources: Las Vegas Review-Journal