2 hours ago Older women look a little accidental of fertility attraction working, adjacent erstwhile utilizing young donor eggs - with a marked drop-off from astir the property of 49, caller probe suggests.
Experts studying 1,774 women accidental the findings situation the thought that donor eggs tin afloat "reset" the reproductive clock, but should not enactment older couples disconnected trying.
Women aged 49 and implicit had treble the hazard of miscarriage than those aged 35 to 40, and were besides little apt to get pregnant.
Researchers judge age-related changes successful the womb lining whitethorn beryllium the origin and could beryllium treatable successful the future.
It mightiness beryllium imaginable to find ways to predict, forestall oregon amended womb age, they say.
Lead researcher Dr Beatrice Crestani, from an assisted reproduction aesculapian institute successful Italy, external, says that reproductive ageing has been seen arsenic an ovarian issue, and that if you regenerate older eggs with younger donor ones, you "reset" the reproductive clock.
"Our findings suggest the representation is much complex," adds Dr Crestani.
In the study, women successful their mid to precocious 30s had a 54% accidental of getting large with donor eggs and IVF treatment; that fell to astir 43% for those aged 49 oregon older.
Live commencement rates declined from 46% to 32%, portion miscarriage rates accrued from 24% to 38%.
The researchers besides noticed age-related changes to the womb lining oregon endometrium - wherever a fertilised ovum oregon embryo implants to turn - successful the older women.
While the thickness was similar, the information declined with age.
Dr Crestani added: "These findings should not discourage women from pursuing donor-egg treatment, due to the fact that occurrence rates stay meaningful adjacent astatine precocious ages.
"However, patients should beryllium counselled that donor eggs cannot wholly destruct the effects of reproductive ageing, peculiarly beyond 49 years."
In the study, the unrecorded commencement complaint was astir 80% for women aged 35-40 and 62.5% among those aged 49 oregon older who transferred each disposable embryos.
English (US)·